Caladrylmakes two lotions – the pink Caladryl Lotion and transparent Caladryl Clear Skin Protectant Lotion varieties. Both formulations help reduce itching and promote soothing of irritated skin, but are made with slightly different ingredients. Choosing the right Caladryl depends on what you’re looking for in terms of relief. Caladryl Lotion includes Calamine as a skin protector and Pramoxine HCI as a topical analgesic. Conversely, Caladryl Clear contains Zinc Acetate for its anti-itch properties, along with Praxmoxine HCI. Both versions provide drying action and temporary itch relief from insect bites, minor skin irritations, sunburn and rash. Turn to Caladryl lotions when you’re dealing with poison ivy, poison oak or poison sumac. Caladryl not only provides temporary itch relief, but helps dries fluids from the blisters that result from coming into contact with these plants.